DNA Gut

DNA Gut tests and reports provide evidence-based, clinically useful insights into human genetic variants that predispose individuals to alterations in gut homeostasis. These alterations are known to have negative consequences for human health.

The report offers personalised diet, lifestyle, and nutraceutical interventions to support relevant pathways and help you achieve and maintain a healthy and resilient gastrointestinal tract.

Clinical Value:

There is significant evidence highlighting the link between the Gut Microbiota and its impact on our genes.

Gut bacteria produce a vast array of compounds (microbial metabolites) that act as messengers; these metabolites can directly or indirectly influence our gene expression. Microbes also influence the expression of genes involved in immune responses and the expression of genes related to lipid metabolism, glucose regulation, and nutrient absorption.

On the other hand, the human genome plays a major role in our gut health by

1. Shaping our gut environment through immune system genes that regulate which bacteria can colonize the gut, encoding proteins that create our gut lining and its protective mucus layer, and encoding digestive enzymes responsible for breaking down food.
2. Influencing nutrient availability by determining how our bodies process and absorb nutrients and what substrates and cofactors are available to important gut enzymes and gut microbiota.

Genetic variants that play a role in these areas may weaken one of the five DNA Gut pillars, which increases risk for altered gut homeostasis, dysbiosis, and predisposition for gut-related health disorders.

The test should be considered for those who are suffering from, or have a predisposition to:

• Irritable bowel syndrome (IBS)
• Chronic bloating, diarrhoea, or constipation
• Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease
• Celiac disease or non-celiac gluten sensitivity
• Gut dysbiosis
• Lactose intolerance
• Food sensitivities
• Autoimmune tendencies and recurrent infections
• Mental health conditions linked to gut health, including mood, cognition, and neurodegenerative conditions
• Anyone seeking preventative, root-cause care

 

The report provides:

• A summary of prioritised pathways
• Genetic variants that impact the Five DNA Gut Health Pillars – Motility, Presence of pathobionts, Aberrant microbial metabolite production, Gut barrier integrity, Immune function
• Gut health predispositions presented as colour-coded areas of potential risk
• Gene and genotype-specific information that is evidence-based and clinically relevant
• Impact of the gene variant on disease risk and how it affects gut health
• Clear explanations and visuals for each gene variant and pathway, coupled with targeted recommendations for diet, supplements, probiotics, and lifestyle, and prompts for further testing (GI-MAP, Zonulin, Gluten Peptide, Stool OMX, SIBO, Toxin Panels, etc.)

 

Assessment of 26 genetic variants involved in:

• Gut-brain axis
• Blood group antigen secretor
• Bacterial sensing and autophagy
• Tight junction proteins
• Vitamin D
• Inflammation
• Oxidative stress
• Detoxification
• Serotonergic pathway
• Gluten Intolerance
• Starch degradation
• Lactose intolerance

 

See HERE a sample report.

 

How does it work?

A BloodSpot Analysis test kit will be sent to you by mail. All it requires is a few drops of blood from one of your fingers. Once completed, a booking can be made with the designated courier to collect the kit (with no additional charges), which will be delivered to the laboratory for testing.

How long will it take for my order to arrive?

All test kits are shipped and are expected to arrive within a few working days. The shipped test kits are considered concluded orders and are non-refundable any longer.

Average processing time:

18-21 days, after the test kits are returned to the lab. Return tests to the lab within 90 days of the order.

How do I take a sample?

All kits include straightforward instructions, allowing you to obtain a sample at home easily.

Are the tests reliable?

Yes! We use leading accredited laboratories to ensure that our testing is of the highest quality.

What will I receive after the test has been processed?

A report will then be generated with detailed information about the tested areas and recommended interventions. The report is presented in a patient-friendly manner so you can understand the possible issues and act upon the clearly formulated recommendations. You will be provided with a secure login on the lab platforms to view and download the results.

What happens after I receive the results?

You will be presented with the option to book an appointment with the doctor to further discuss the test results. The appointment will last about 30-60 minutes (includes the time the doctor needs to study the results), during which professional interpretation, further advice, and a possible therapeutic plan, based on your results, will be provided.

Privacy policy:

The DNA and the original sample material are destroyed after 3 months, so that there are no names or other identifiers on the samples. The samples are analysed only for the SNPs that are included in the tests at DNALife, and no other research or analyses are performed without separate permission from the patient. We do not give or sell the results to any third parties.

Important note:

Send us through the Contact Form (typed in the Comment field) your birthday, as well as your weight and height. This data is a requirement for the lab analysis.